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The investigational glucose-dependent insulinotropic polypeptide/GLP-1 receptor agonist tirzepatide led to significant and superior HbA1c and body weight reductions for adults with type 2 diabetes vs. SURPASS-2 study data show. Additionally, a prespecified exploratory analysis showed 60% of participants on the highest, 15-mg dose of tirzepatide (Eli Lilly) achieved a composite endpoint of an HbA1c of 6.5% or lower and weight loss of 10% or greater with no reports of severe hypoglycemia, compared with 22% of participants assigned 1 mg semaglutide (Ozempic, Novo Nordisk). "The results of the trial demonstrate that tirzepatide provided a degree of efficacy with respect to HbA1c lowering and reduction in body weight that has not previously been seen in clinical trials assessing antihyperglycemic agents," Juan Pablo Frias, MD, FACE, medical director and a principal investigator of the National Research Institute in Los Angeles, told Healio. For the phase 3 trial, Frias and colleagues analyzed data from 1,879 adults with type 2 diabetes inadequately controlled with metformin therapy of at least 1,500 mg daily (mean age, 57 years; mean baseline HbA1c, 8.28%; mean baseline weight, 93.7 kg).



Researchers randomly assigned participants a once-weekly subcutaneous injection of 5 mg, 10 mg or 15 mg tirzepatide or 1 mg [[https://www.savethestudent.org/?s=semaglutide|semaglutide]] for 40 weeks, followed by a 4-week safety follow-up period. Primary endpoint was change in HbA1c from baseline to 40 weeks. The findings were presented as a late-breaking poster presentation and simultaneously published in The New England Journal of Medicine. Researchers found the estimated mean change from baseline in the HbA1c level was -2.01 percentage points, -2.24 percentage points and -2.3 percentage points with the 5 mg, 10 mg and 15 mg doses of tirzepatide, respectively, and -1.86 percentage points with semaglutide. The estimated differences between the 5 mg, 10 mg and 15 mg tirzepatide groups and the semaglutide group were -0.15 percentage points (95% CI, -0.28 to -0.03), -0.39 percentage points (95% CI, -0.51 to -0.26) and -0.45 percentage points (95% CI, -0.57 to -0.32), respectively. At all doses, tirzepatide was noninferior and superior to semaglutide. Reductions in body weight were greater with tirzepatide vs.
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